This theme broadly represents research programs in radiation oncology physics, basic dosimetry, radiation detectors, Monte Carlo simulations in radiation therapy, physics of four-dimensional adaptive radiation therapy, physics of brachytherapy, novel computational techniques, instrumentation hardware and computational software, radiation physics applied to shielding and radioprotection, etc. Research by Beaulieu and his group investigates advanced dose calculation for brachytherapy and applications of fiber detectors in accurate dosimetry. Devic is an expert on radiochromic film dosimetry and his group develops new film-based detectors with advanced properties for applications in radiation therapy and diagnostic radiology. Després’ group uses graphical processor units to advance dose calculation and image processing in radiation oncology and radiology while Seuntjens’ group combines experimental and computational methodologies for accurate dosimetry in reference conditions as well as for applications in the clinical domain such as the development of new treatment techniques. Collaborators at the National Research Council, McEwen and Ross , develop new primary dosimetry standards and are key figures in radiation dosimetry protocol development. Paganetti is a key research scientist, heading the Harvard research group on computational proton therapy physics in Boston. Over thirty staff clinical medical physics collaborators at MUHC , JGH  and CHUQ play an important role in the clinical translation aspects of the research projects and in some of the courses established in the MPRTN CREATE program.